Emma Hernandez Sanabria

Telephone number: 
+32 9/264 59 80
Postdoctoral staff

I find particularly challenging and exciting exploring the links among microbial consortia in various environments. I am also fascinated by cows.

  • PhD Agricultural, Food and Nutritional Sciences (Rumen Microbial Genomics), University of Alberta, Canada (2011)
  • MSc Animal Production and Nutrition, The University of Aberdeen, UK (2005)
  • Doctor in Veterinary Medicine, Universidad Autónoma de Querétaro, Mexico (2003)


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Project Translational Intestinal Models (TRAIN)

Alterations on inflammatory pathways lead to aberrant expression of cyclooxygenase-2 (COX-2) in colon carcinogenesis (CRC). The efficacy of COX inhibitors (coxibs) for successfully reducing CRC recurrence further confirmed the key role of COX-2. Alas, continuous COX-2 inhibition may increase the risk of a cardiovascular event. Currently, little information is available on how inter-individual variations in colon microbiota impact coxib disposition and overall celecoxib disposition. Thus, we aim to determine the baseline microbiota activities and metabolic response, to reveal whether microbial drug metabolism impacts the conversion process.

Selected key publications: 
Hernandez-Sanabria, E., Goonewardene, L.A., Wang, Z., Durunna, O.N., Moore, S.S. and Guan, L.L., 2012. Impact of Feed Efficiency and Diet on Adaptive Variations in the Bacterial Community in the Rumen Fluid of Cattle. Applied and Environmental Microbiology, 78(4), p.1203.
Hernandez-Sanabria, E., Le Luo Guan, L.A.G., Li, M., Mujibi, D.F., Stothard, P., Moore, S.S. and Leon-Quintero, M.C., 2010. Correlation of Particular Bacterial PCR-Denaturing Gradient Gel Electrophoresis Patterns with Bovine Ruminal Fermentation Parameters and Feed Efficiency Traits. Applied and Environmental Microbiology, 76(19), p.6338.
Hernandez-Sanabria, E., Goonewardene, L.A., Wang, Z., Zhou, M., Moore, S.S. and Guan, L.L., 2012. Influence of sire breed on the interplay among rumen microbial populations inhabiting the rumen liquid of the progeny in beef cattle. PloS one, 8(3), pp.e58461-e58461.
Zhou, M., Hernandez-Sanabria, E. and Guan, L.L., 2010. Characterization of Variation in Rumen Methanogenic Communities under Different Dietary and Host Feed Efficiency Conditions, as Determined by PCR-Denaturing Gradient Gel Electrophoresis Analysis. Applied and environmental microbiology AEM.
Henderson, G., Cox, F., Ganesh, S., Jonker, A. and Young, W., 2015. Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range. Scientific Reports, 5.
Grunert, O., Hernandez-Sanabria, E., Vilchez-Vargas, R., Jauregui, R., Pieper, D.H., Perneel, M., Van Labeke, M.C., Reheul, D. and Boon, N., 2016. Mineral and organic growing media have distinct community structure, stability and functionality in soilless culture systems. Scientific reports, 6, p.18837.
Hernandez-Sanabria, E., Slomka, V., Herrero, E.R., Kerckhof, F.M., Zaidel, L., Teughels, W. and Boon, N., 2017. In vitro Increased Respiratory Activity of Selected Oral Bacteria May Explain Competitive and Collaborative Interactions in the Oral Microbiome. Frontiers in Cellular and Infection Microbiology, 7, p.235.
De Weirdt, R., Hernandez‐Sanabria, E., Fievez, V., Mees, E., Geirnaert, A., Van Herreweghen, F., Vilchez‐Vargas, R., Van den Abbeele, P., Jauregui, R., Pieper, D.H. and Vlaeminck, B., 2017. Mucosa‐associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly‐unsaturated fat. Environmental microbiology, 19(2), pp.722-739.
Slomka, V., Hernandez‐Sanabria, E., Herrero, E.R., Zaidel, L., Bernaerts, K., Boon, N., Quirynen, M. and Teughels, W., 2017. Nutritional stimulation of commensal oral bacteria suppresses pathogens: the prebiotic concept. Journal of Clinical Periodontology, 44(4), pp.344-352.
Truchado, P., Hernandez-Sanabria, E., Salden, BN., Van den Abbeele, P., Vilchez-Vargas, R., Jauregui, R., Pieper, DH., Possemiers, S., Van de Wiele, T. 2017. Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem (M-SHIME). Journal of Functional Foods, 32, 226-237